Toward a Durable Anti-HIV Gene Therapy Based on RNA Interference
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چکیده
منابع مشابه
The future of HIV infection: gene therapy and RNA interference.
The description of the mechanism of RNA interference (RNAi) has generated enormous interest in the biomedical field. A previously unrecognized pathway in which small interfering, 21 to 23 mer, double-stranded RNA (siRNA) mediates sequence-specific degradation of mRNA is becoming one the most useful techniques in cell biology and genetics research. Based on the potency, specificity and physiolog...
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Neurodegenerative disorders represent a major class of disorders for which thus far any effective small molecule drug therapy has failed to emerge. RNA interference (RNAi), by which disease genes such as those identified for spino-cerebellar ataxia and Huntington's disease can be specifically silenced, has great potential in becoming a successful therapeutic strategy for these diseases. RNAi ha...
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In recent years, the contribution of chemotherapy to infection by the human immunodeficiency virus (HIV) has been extremely significant with regard to survival and improvement of quality of life. Nevertheless, a cure for this infection remains an uncertain objective as the virus cannot be completely eliminated, but remains latent and able to reactivate in a small cell reservoir. Consequently, a...
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Gene therapy was originally thought to cover replacement of malfunctioning genes in treatment of various diseases. Today, the field has been expanded to application of viral and non-viral vectors for delivery of recombinant proteins for the compensation of missing or insufficient proteins, anti-cancer genes and proteins for destruction of tumor cells, immunostimulatory genes and proteins for st...
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Background: The rapid increase of HIV-1 strains resistant to current antiretroviral drugs is a challenge for successful AIDS therapy. This necessitates the development of novel drugs, and to this end, availability of screening systems for in vitro drug discovery is a priority. Herein, we report the modification of a previously developed system for increased sensitivity, ease of use, and cost-ef...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2009
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.2009.04972.x